Characteristics of pneumoconiosis on multi-detector row CT and its' anatomic-pathologic basis / 生物医学工程学杂志

In order to investigate the fine distinction of the tomographic images and the dominant anatomic distributions, we carefully reviewed and analyzed the features and predominant anatomic distribution of forty-nine pneumoconiosis patients with confirmed diagnosis on multi-detector row CT (MDCT). It was found that the round and small opacity p and irregular small opacity were mostly shown in the MDCT features of pneumoconiosis, while the large opacity and progressive massive fibrosis (PMF) were less frequently depicted in the MDCT. Distributions of round and small opacity and irregular small opacity in the six lung lobes were significantly different (P < 0.01). The most common p opacity was significantly seen in the upper and lower left lungs as well as in the upper right lung's opacity was in the upper left lung as well as lower left and right lungs. The large opacity commonly distributed in upper left and right lungs, while the PMF was often shown in both of two lungs. The results demonstrated that the MDCT could be an effective modality for detecting tiny lesions and anatomic distribution of pneumoconiosis, and it would be helpful for early diagnosis and accurate staging of the pneumoconiosis disease.

16-Detector row CT features and related anatomic-pathology basis of idiopathic pulmonary fibrosis / 生物医学工程学杂志

The objective of this study was to elucidata the correlation of 16-detector row CT features with the complications and anatomic-pathology of the disease in patients with idiopathic pulmonary fibrosis (IPF). The 16-detector row CT appearances and predominant anatomic distribution were analyzed in 38 cases of IPF. Of the 14 patients (36.8%) with honeycomb lung, 10 (71.4%) had honeycomb appearances predominantly distributed in the peripheral zone of the middle and lower lobes, particularly in the basal segments of the lower lobes. 11 patients (78.6%) had the clinical duration of honeycomb lung for more than 3 years. The interlobular interstitial thickening was seen in 16 cases (42.1%), the interlobular septa thickening in 20 cases (52.6%); and the thickened bronchus-vascular bundle in 9 cases (23.7%). The above-mentioned three kinds of CT features observably distributed in the peripheral zone of the middle and lower lobes, in the basal segments of the lower lobes, and in the lower lobes and middle lobe of right lung in the middle of the zone, respectively. In 15 patients (39.5%), ground-glass opacity was predominantly distributed in the peripheral zone of lung and in the basal segments of the lower lobes; and the clinical duration lasted less than 1 year was seen in 10 cases (66.7%). These results indicated that some characteristic manifestations with pathologic variation and predominant anatomic distribution of IDF can be shown on 16-detector row CT.

Pneumoconiosis: high-resolution CT characteristics and patho-physiology / 生物医学工程学杂志

Long-term exposure of the human body to powder-dust environment commonly results in pneumoconiosis, such as silicosis, coal worker's pneumoconiosis and asbestosis. The pathological features of pneumoconiosis include lung's nodules and fibrosis. Plain film and computed tomography (CT) are the main imaging modalities for detecting pneumoconiosis, especially the high-resolution CT (HRCT), multi-detector row CT (MDCT) and related post-processing techniques are helpful in detecting the tiny pathological manifestations of pneumoconiosis so as to make early diagnosis. Furthermore, the functional MDCT could comprehensively assess the pulmonary physiological functions of the patient with pneumoconiosis.

Clinical application of 64-slice CT angiography in the evaluation of lumen before and after coronary artery stent implantation / 生物医学工程学杂志

This is a retrospective study aimed at the clinical application of 64-slice computed tomography angiography (CTA) in evaluation the lumen before and after coronary artery stent implantation. We collected the coronary artery imaging data of 46 patients undergoing 64-slice CT before coronary artery stent implantation from July 2006 through May 2007; we also collected the data of 21 patients with 34 coronary artery stents in the same period to determine the diagnostic accuracy of CTA before and after coronary artery stent implantation. The results showed that, in 46 patients, 64-slice CT enabled the visualization of the entire coronary tree with diagnostic image quality. Sensitivity, specificity, and accuracy for the detection of stenosis > or = 50% were 92.11%, 95.64% and 94.97%, respectively. In 21 patients with 34 stents implanted, 23 (67.65%) stents showed no stenosis, 8 (23.53%) stents showed low degree of restenosis, and 3 (8.83%) stents showed high degree of restenosis. In conclusion, we can accurately evaluate the degree of stenosis of lumen before and after coronary artery stent implantation with the application of 64-slice CTA.

Helical CT Findings and Misdiagnosis of Pulmonary Thromboembolism / 实用放射学杂志

Objective To investigate the diagnostic value of helical CT study in pulmonary thromboembolism.Methods A retrospective analysis was made on 16 misdiagnosed cases,studied previously with plain CT scanning.Results All of the 16 cases had positive findings on CT scanning,with sensitivity 100%.Among them,11 cases were misdiagnosed as pleural effusion plus pneumonia;3 pleural effusion;and 2,each of organized pneumonia and peripheral lung cancer.Conclusion The strong evidence of the disease could be given even with plain CT studies.The procedure is simple,safe and reliable,If a patient is suspected with the disease,and if CT is available in the hospital,CT should be the first choice in the study.

Comparison of effect of DEET with different concentrations in prevention of Schistosoma japonicum infection in mice / 中国血吸虫病防治杂志

ObjectiveTo explore the efficiency of N,N-diethyl-m-toluamide (DEET) with different concentrations in prevention of Schistosoma japonicum infection in mice.MethodsKunming-mice were randomly divided into four groups for the application of the vaseline ointment with different DEET concentrations (0,10%,20% and 30%). After the abdominal skin of the mice were smeared with those DEETs above mentioned and dipped into water for 10,30 min,1,2 h and 4 h, the mice were infected with (505) cercariae respectively. After infected for 6-7 weeks, all of the mice were sacrificed,and by perfusing heart the worms were collected and counted.Worm reduction rates were calculated and the rank sum tests were carried out. ResultsAt the time points of 1,2 and 4 h , the worm reduction rates were 78.34%,63.15% and 40.23% for 10% DEET vaseline ointment, 98.61%,93.37% and 75.74% for 20% DEET vaseline ointment and 100.00%,98.61% and 93.07% for 30% DEET vaseline oinment respectively(H =10.06,10.84,10.80,all P

Comparison of effect of three DEET formulations preventing Schistosoma japonicum infection in mice / 中国血吸虫病防治杂志

Objective To compare the effica cy of three N,N-diethyl-m-toluamide (DEET) formulations against Schistosoma japonicum infection in mice. Methods Three 10% DEET formulations (DEET isopropanol solution,DEET cr eam and DEET vaseline ointment)were prepared and two experiments, no-dipping or dipping after applying DEET preparation ,were designed. In each experiment, mice were randomly divided into three experiment groups and three control groups . D ifferent DEET preparations were applied in the experiment groups and isopropanol solution, “yumeijing” cream , vaseline ointment were applied in the control g roups, respectively. At different time points after skin application (0.5, 1, 2 , 4 h and 8 h),the mice were infected with (50?5) Schistosoma j apon icum cercariae on the abdominal skin in no dipping experiment. I n dipping experiment,after mice skin were applied and were dipped for 10,30 min, 1 ,2 h and 4 h, respectively, the mice were infected with (50?5) cercariae. Af ter 6-7 weeks ,all the mice were sacrificed and the worms were collected by hea rt perfusion and counted.Worm reduction rates were calculated and rank sum tests w ere carried out. Results In no-dipping experim ent,three DEET formulations provided 100.0% protection in mice at least for 1 h .A t 2 ,4 h and 8 h ,the worm reduction rates were 94.8%,89.9% and 13.3% for DE ET isopropanol solution, 100.0%,97.8% and 50.7% for DEET cream and 100.0%,9 9.0% and 9 8.0% for DEET vaseline oinment, respectively. In dipping experi-ment, given 50.0% wor m reduction rate as efficient in preventing penetration by the cercariae, the e ffective times were 10 min for DEET isopropanol solution,30 min for DEET cream a nd 2 h for DEET vaseline oinment,respectively. Conclusion Three DEET formulations are effectiv e in preventing Schistosoma japonicum infection in mice.DEET vaseline oinment can provide better protection than the other two D EET formulations.